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Siren, L.L.C.
CIK 2005245 · 2024-Q4 · 2 filing(s) · prev: 2024-Q3
Total Portfolio Value
$2.3T
Positions
119
16 exited vs prev quarter
Latest Filing
2024-Q4
Due Diligence Score
Institutional quality assessment based on 13F data
F
33 / 100
Filing Longevity3/30
2 quarters of history
Portfolio Breadth3/25
117 positions
Equity Purity20/20
1 options positions (0.8%)
Concentration Balance7/25
Top-5 = 35.9% of portfolio
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AI Portfolio Analysis
Claude-powered institutional analyst commentary
Portfolio Profile
Relative positioning across key dimensions (0–100)
Top Holdings by Value
Top 30 positions by value
| # | Issuer | Class | CUSIP | Value | Shares | % Portfolio | Type |
|---|---|---|---|---|---|---|---|
| 1 | ▲Scholar Rock Holding Corp | COM | 80706P103 | $399.8B | 9,250,005 | 17.66% | EQ |
| 2 | ▼Beigene Ltd | SPONSORED ADR | 07725L102 | $120.7B | 653,721 | 5.33% | EQ |
| 3 | ▼Kymera Therapeutics Inc | COM | 501575104 | $119.5B | 2,969,733 | 5.28% | EQ |
| 4 | ▲Apellis Pharmaceuticals Inc | COM | 03753U106 | $89.9B | 2,816,258 | 3.97% | EQ |
| 5 | ▲Crinetics Pharmaceuticals Inc | COM | 22663K107 | $82.3B | 1,609,652 | 3.64% | EQ |
| 6 | ▼argenx SE | SPONSORED ADR | 04016X101 | $70.8B | 115,045 | 3.13% | EQ |
| 7 | ▼Bicara Therapeutics Inc | COM | 055477103 | $57.0B | 3,272,827 | 2.52% | EQ |
| 8 | ▲Arrowhead Pharmaceuticals Inc | COM | 04280A100 | $54.6B | 2,901,681 | 2.41% | EQ |
| 9 | ▲NewAmsterdam Pharma Company NV | ORDINARY SHARES | N62509109 | $53.9B | 2,095,638 | 2.38% | EQ |
| 10 | NEWSepterna Inc | COM | 81734D104 | $50.4B | 2,202,514 | 2.23% | EQ |
| 11 | ▼Centessa Pharmaceuticals PLC | SPONSORED ADS | 152309100 | $50.3B | 3,004,677 | 2.22% | EQ |
| 12 | ▲SpringWorks Therapeutics Inc | COM | 85205L107 | $49.8B | 1,377,701 | 2.20% | EQ |
| 13 | ▲Neumora Therapeutics Inc | COM | 640979100 | $46.6B | 4,396,100 | 2.06% | EQ |
| 14 | ▼WAVE Life Sciences Ltd | SHS | Y95308105 | $46.4B | 3,750,491 | 2.05% | EQ |
| 15 | ▼Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | $40.9B | 297,321 | 1.81% | EQ |
| 16 | NEWMadrigal Pharmaceuticals Inc | COM | 558868105 | $38.9B | 125,942 | 1.72% | EQ |
| 17 | ▲Taboola.com Ltd | ORD SHS | M8744T106 | $36.4B | 9,969,495 | 1.61% | EQ |
| 18 | NEWApogee Therapeutics Inc | COM | 03770N101 | $33.9B | 747,325 | 1.50% | EQ |
| 19 | ▼Merus NV | COM | N5749R100 | $33.0B | 784,412 | 1.46% | EQ |
| 20 | ▼Avidity Biosciences Inc | COM | 05370A108 | $32.8B | 1,127,295 | 1.45% | EQ |
| 21 | ▼Vera Therapeutics Inc | CL A | 92337R101 | $32.1B | 758,465 | 1.42% | EQ |
| 22 | ▼Dyne Therapeutics Inc | COM | 26818M108 | $31.7B | 1,347,456 | 1.40% | EQ |
| 23 | ▼Xenon Pharmaceuticals Inc | COM | 98420N105 | $29.2B | 743,769 | 1.29% | EQ |
| 24 | ▼Lexicon Pharmaceuticals Inc | COM NEW | 528872302 | $28.8B | 38,918,903 | 1.27% | EQ |
| 25 | NEWBicycle Therapeutics PLC | SPONSORED ADS | 088786108 | $25.8B | 1,839,398 | 1.14% | EQ |
| 26 | ▼Revolution Medicines Inc | COM | 76155X100 | $25.0B | 571,548 | 1.10% | EQ |
| 27 | ▼Vaxcyte Inc | COM | 92243G108 | $24.6B | 299,991 | 1.08% | EQ |
| 28 | ▼Arcus Biosciences Inc | COM | 03969F109 | $24.0B | 1,612,077 | 1.06% | EQ |
| 29 | ▼Erasca Inc | COM | 29479A108 | $22.2B | 8,857,179 | 0.98% | EQ |
| 30 | NEWStoke Therapeutics Inc | COM | 86150R107 | $22.1B | 2,000,000 | 0.97% | EQ |
| 31 | ▼IGM Biosciences Inc | COM | 449585108 | $20.3B | 3,330,422 | 0.90% | EQ |
| 32 | ▲Edgewise Therapeutics Inc | COM | 28036F105 | $19.6B | 734,343 | 0.87% | EQ |
| 33 | ▼Silence Therapeutics PLC | ADS | 82686Q101 | $19.5B | 2,831,770 | 0.86% | EQ |
| 34 | ▼Cytokinetics Inc | COM NEW | 23282W605 | $18.9B | 402,323 | 0.84% | EQ |
| 35 | ▼Denali Therapeutics Inc | COM | 24823R105 | $17.0B | 834,028 | 0.75% | EQ |
| 36 | ▲Korro Bio Inc | COM | 500946108 | $15.9B | 418,833 | 0.70% | EQ |
| 37 | NEWSoleno Therapeutics Inc | COM | 834203309 | $15.8B | 351,818 | 0.70% | EQ |
| 38 | ▼Prothena Corporation PLC | SHS | G72800108 | $15.2B | 1,099,840 | 0.67% | EQ |
| 39 | ▼Solid Biosciences Inc | COM NEW | 83422E204 | $15.0B | 3,749,041 | 0.66% | EQ |
| 40 | ▼Cullinan Therapeutics Inc | COM | 230031106 | $14.8B | 1,211,357 | 0.65% | EQ |
| 41 | NEWUpstream Bio Inc | COM | 91678A107 | $13.2B | 800,000 | 0.58% | EQ |
| 42 | NEWTrevi Therapeutics Inc | COM | 89532M101 | $12.0B | 2,906,060 | 0.53% | EQ |
| 43 | ▼Kura Oncology Inc | COM | 50127T109 | $11.7B | 1,339,942 | 0.52% | EQ |
| 44 | ▲Taysha Gene Therapies Inc | COM SHS | 877619106 | $11.4B | 6,602,475 | 0.50% | EQ |
| 45 | ▲Remitly Global Inc | COM | 75960P104 | $10.5B | 465,449 | 0.46% | EQ |
| 46 | ▲Cartesian Therapeutics Inc | COM NEW | 816212302 | $10.2B | 572,236 | 0.45% | EQ |
| 47 | ▲Microsoft Corp | COM | 594918104 | $9.7B | 23,000 | 0.43% | EQ |
| 48 | NEWJanux Therapeutics Inc | COM | 47103J105 | $9.4B | 175,000 | 0.41% | EQ |
| 49 | ▲Seer Inc | COM CL A | 81578P106 | $9.2B | 4,000,000 | 0.41% | EQ |
| 50 | ▼Ionis Pharmaceuticals Inc | COM | 462222100 | $8.7B | 250,000 | 0.39% | EQ |
| 51 | NEWSpyre Therapeutics Inc | COM NEW | 00773J202 | $8.7B | 374,000 | 0.38% | EQ |
| 52 | ▲CrowdStrike Holdings Inc | CL A | 22788C105 | $8.2B | 24,000 | 0.36% | EQ |
| 53 | ▼Iovance Biotherapeutics Inc | COM | 462260100 | $8.2B | 1,106,040 | 0.36% | EQ |
| 54 | ▼Oric Pharmaceuticals Inc | COM | 68622P109 | $8.1B | 1,007,575 | 0.36% | EQ |
| 55 | ▼Tango Therapeutics Inc | COM | 87583X109 | $8.0B | 2,603,897 | 0.36% | EQ |
| 56 | ▲Amazon.com Inc | COM | 023135106 | $8.0B | 36,500 | 0.35% | EQ |
| 57 | NEWRocket Pharmaceuticals Inc | COM | 77313F106 | $7.5B | 600,000 | 0.33% | EQ |
| 58 | ▲IONQ Inc | COM | 46222L108 | $7.1B | 170,000 | 0.31% | EQ |
| 59 | ▼IHS Holding Limited | ORD SHS | G4701H109 | $6.9B | 2,357,520 | 0.30% | EQ |
| 60 | ▼Rapport Therapeutics Inc | COM | 75383L102 | $6.8B | 384,197 | 0.30% | EQ |
| 61 | ▲NVIDIA Corp | COM | 67066G104 | $6.6B | 48,932 | 0.29% | EQ |
| 62 | ▼ServiceNow Inc | COM | 81762P102 | $5.9B | 5,605 | 0.26% | EQ |
| 63 | ▼ACELYRIN Inc | COM | 00445A100 | $5.4B | 1,729,665 | 0.24% | EQ |
| 64 | ▼PDD Holdings Inc | SPONSORED ADS | 722304102 | $5.1B | 52,901 | 0.23% | EQ |
| 65 | ▼Gossamer Bio Inc | COM | 38341P102 | $4.7B | 5,208,968 | 0.21% | EQ |
| 66 | ▲Dynatrace Inc | COM NEW | 268150109 | $4.5B | 82,729 | 0.20% | EQ |
| 67 | NEWBoeing Co | COM | 097023105 | $4.4B | 25,000 | 0.20% | EQ |
| 68 | ▲New Oriental Education & Technology Group Inc | SPON ADR | 647581206 | $4.4B | 68,500 | 0.19% | EQ |
| 69 | ▲Datadog Inc | CL A COM | 23804L103 | $4.3B | 30,425 | 0.19% | EQ |
| 70 | NEWProQR Therapeutics NV | SHS EURO | N71542109 | $4.2B | 1,575,000 | 0.18% | EQ |
| 71 | ▼Lexeo Therapeutics Inc | COM | 52886X107 | $4.0B | 603,435 | 0.18% | EQ |
| 72 | ▲Adobe Inc | COM | 00724F101 | $3.9B | 8,798 | 0.17% | EQ |
| 73 | ▼Phathom Pharmaceuticals Inc | COM | 71722W107 | $3.7B | 460,753 | 0.17% | EQ |
| 74 | ▼Instil Bio Inc | COM NEW | 45783C200 | $3.7B | 192,433 | 0.16% | EQ |
| 75 | ▲Jfrog Ltd | ORD SHS | M6191J100 | $3.5B | 120,116 | 0.16% | EQ |
| 76 | ▼Foghorn Therapeutics Inc. | COM | 344174107 | $3.4B | 720,720 | 0.15% | EQ |
| 77 | ▼Vigil Neuroscience Inc | COM | 92673K108 | $3.4B | 1,991,038 | 0.15% | EQ |
| 78 | NEWNebius Group NV | SHS CLASS A | N97284108 | $3.3B | 120,000 | 0.15% | EQ |
| 79 | ▲Sagimet Biosciences Inc | COM SER A | 786700104 | $3.3B | 724,771 | 0.14% | EQ |
| 80 | ▼Generation Bio Co | COM | 37148K100 | $3.2B | 2,982,733 | 0.14% | EQ |
| 81 | ▼Taiwan Semiconductor Manufacturing Co Ltd | SPONSORED ADS | 874039100 | $3.0B | 15,000 | 0.13% | EQ |
| 82 | NEWFreeport-McMoRan Inc | CL B | 35671D857 | $2.9B | 75,000 | 0.13% | EQ |
| 83 | ▼Allovir Inc | COM | 019818103 | $2.8B | 6,597,167 | 0.12% | EQ |
| 84 | ▼Ovid Therapeutics Inc | COM | 690469101 | $2.7B | 2,850,000 | 0.12% | EQ |
| 85 | ▼Sea Ltd | SPONSORED ADS | 81141R100 | $2.7B | 25,000 | 0.12% | EQ |
| 86 | ▲Elastic NV | ORD SHS | N14506104 | $2.5B | 25,000 | 0.11% | EQ |
| 87 | ▼Qualcomm Inc | COM | 747525103 | $2.3B | 15,000 | 0.10% | EQ |
| 88 | ▼BIOAGE Labs Inc | COM | 09077V100 | $2.2B | 388,000 | 0.10% | EQ |
| 89 | ▼Black Diamond Therapeutics Inc | COM | 09203E105 | $2.2B | 1,046,517 | 0.10% | EQ |
| 90 | ▼Regenxbio Inc | COM | 75901B107 | $2.2B | 284,000 | 0.10% | EQ |
| 91 | ▼Tourmaline Bio Inc | COM | 89157D105 | $1.9B | 91,426 | 0.08% | EQ |
| 92 | ▼Procore Technologies Inc | COM | 74275K108 | $1.5B | 20,000 | 0.07% | EQ |
| 93 | ▼Applied Therapeutics Inc | COM | 03828A101 | $1.4B | 1,633,768 | 0.06% | EQ |
| 94 | ▼Alphabet Inc | CAP STK CL A | 02079K305 | $1.3B | 7,000 | 0.06% | EQ |
| 95 | ▲PayPal Holdings Inc | COM | 70450Y103 | $1.3B | 15,000 | 0.06% | EQ |
| 96 | ▼HOOKIPA Pharma Inc | COM NEW | 43906K209 | $1.1B | 566,640 | 0.05% | EQ |
| 97 | NEWHCA Healthcare Inc | COM | 40412C101 | $1.1B | 3,750 | 0.05% | EQ |
| 98 | ▼Ke Holdings Inc | SPONSORED ADS | 482497104 | $1.1B | 60,000 | 0.05% | EQ |
| 99 | NEWWorkiva Inc | COM CL A | 98139A105 | $1.1B | 10,000 | 0.05% | EQ |
| 100 | ▼Palo Alto Networks Inc | COM | 697435105 | $1.1B | 6,000 | 0.05% | EQ |
| 101 | ▼Omega Therapeutics Inc | COMMON STOCK | 68217N105 | $986.8M | 1,323,530 | 0.04% | EQ |
| 102 | NEWCouchbase Inc | COM | 22207T101 | $935.4M | 60,000 | 0.04% | EQ |
| 103 | ▲Achilles Therapeutics PLC | SPONSORED ADS | 00449L102 | $861.1M | 755,375 | 0.04% | EQ |
| 104 | NEWFerrari NV | COM | N3167Y103 | $854.5M | 2,000 | 0.04% | EQ |
| 105 | ▼Intel Corp | COM | 458140100 | $802.0M | 40,000 | 0.04% | EQ |
| 106 | ▼Kronos Bio Inc | COM | 50107A104 | $800.8M | 842,954 | 0.04% | EQ |
| 107 | ▲Dollar Tree Inc | COM | 256746108 | $749.4M | 10,000 | 0.03% | EQ |
| 108 | ▼Occidental Petroleum Corp | COM | 674599105 | $741.1M | 15,000 | 0.03% | EQ |
| 109 | ▼Meta Platforms Inc | CL A | 30303M102 | $585.5M | 1,000 | 0.03% | EQ |
| 110 | ▲Remitly Global Inc | COM | 75960P104 | $564.3M | 25,000 | 0.02% | EQ |
| 111 | NEWMarvell Technology Inc | COM | 573874104 | $552.3M | 5,000 | 0.02% | EQ |
| 112 | ▼Nu Holdings Ltd | ORD SHS CL A | G6683N103 | $518.0M | 50,000 | 0.02% | EQ |
| 113 | ▲Ironwood Pharmaceuticals Inc | COM CL A | 46333X108 | $489.7M | 110,532 | 0.02% | EQ |
| 114 | NEWMonday.Com Ltd | SHS | M7S64H106 | $470.9M | 2,000 | 0.02% | EQ |
| 115 | NEWSEMrush Holdings Inc | CL A COM | 81686C104 | $415.8M | 35,000 | 0.02% | EQ |
| 116 | ▲Cyclerion Therapeutics Inc | COM | 23255M204 | $374.0M | 116,155 | 0.02% | EQ |
| 117 | ▼Kanzhun Ltd | SPONSORED ADS | 48553T106 | $345.0M | 25,000 | 0.02% | EQ |
| 118 | ▼Gossamer Bio Inc | COM | 38341P102 | $187.3M | 207,000 | 0.01% | Call |
| 119 | ▼Caribou Biosciences Inc | COM | 142038108 | $167.5M | 105,347 | 0.01% | EQ |